Preconditioning and Arrhythmias
نویسندگان
چکیده
منابع مشابه
Preconditioning and arrhythmias.
Abrief episode of myocardial ischemia confers endogenous cardioprotection during a subsequent prolonged period of ischemia. This phenomenon, known as preconditioning,1 offers one of the most powerful mechanisms for reducing the speed and extent of myocardial cell damage resulting from an acute or sustained ischemic insult. This protection has been shown to occur in a wide variety of animal spec...
متن کاملGap junctions in preconditioning against arrhythmias.
Ischemic preconditioning is a natural mechanism by which brief periods of ischemia–reperfusion initiate a complex cascade of events that culminate in the protection of the heart against a subsequent sustained ischemia, reducing infarct size, postischemic dysfunction, and the incidence of arrhythmias [1]. In essence, endogenous or exogenous triggers released during ischemic or pharmacological pr...
متن کاملIschemia and reperfusion-induced arrhythmias: role of hyperoxic preconditioning.
BACKGROUND Hyperoxic preconditioning is known to protect the heart against necrosis and contractile dysfunction, but protection against arrhythmias has not been well characterized. OBJECTIVE The authors hypothesized that pre-exposure to normobaric hyperoxia (H) reduces ischemia and reperfusion-induced arrhythmias in isolated rat hearts. METHODS Following 60 and 180 min of hyperoxia treatmen...
متن کاملPreconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model
Abstract Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effect...
متن کاملRole of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning.
Overexpression of mitochondrial uncoupling proteins (UCPs) attenuates ischemia-reperfusion (I/R) injury in cultured cardiomyocytes. However, it is not known whether UCPs play an essential role in cardioprotection in the intact heart. This study evaluated the cardioprotective efficacy of UCPs against I/R injury and characterized the mechanism of UCP-mediated protection in addition to the role of...
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000041803.03687.7a